The Most Effective Weight Training, Cardio & Nutrition for Women | Dr. Lauren Colenso-Semple

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Dr. Lauren Colenso-Semple
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~4 min
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16 Feb 2026
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KEYPOINTS

  • 01

    Muscle responds to training the same way in women and men

    Colenso-Semple, an exercise scientist, says muscle protein synthesis and growth after training or protein are very similar in both sexes. Men start with more muscle because of the testosterone surge at puberty, but untrained men and women gain similar relative size once they start lifting.

  • 02

    Natural testosterone differences within the normal range don't predict gains

    A man at 400 ng/dL doesn't build noticeably more muscle than one at 600 if both are within the roughly 300–900 ng/dL range, and the same holds for women. Only well-above-normal doses from steroids change the picture. Post-workout spikes in testosterone and growth hormone were once thought to drive growth, but they don't predict long-term gains, so programs built to maximize those spikes miss the point.

  • 03

    Lifting heavy won't make women bulky by accident

    She credits the bikini category in bodybuilding, group fitness and CrossFit with making lifting feel feminine. Yet 'where are all of these bulky women?' Very muscular physiques take years of hard work and often drugs. Keeping teenage girls out of weight rooms is a cultural habit, not a safety issue.

  • 04

    A good beginner program trains the whole body two or three times a week

    Treat lifting as a way to grow muscle, not shrink. Train all major muscle groups two or three times a week (upper/lower splits make sense at four days, more detailed splits at five or six). After warm-ups, do at least 2 hard sets per exercise, ideally 3, and up to 4, since more is probably overkill. Mix squat-type and hip-hinge movements, and progress load or reps month to month.

  • 05

    Any rep range builds muscle if you train close to failure

    Stopping one or two reps short of failure is enough. Growth is similar with heavy, low-rep sets and lighter, high-rep sets, but heavy sets need many more sets to match total volume. To maximize a one-rep max, you need some very heavy, low-rep training. She is skeptical of partial reps and tempo tricks because they're hard to repeat consistently.

  • 06

    Rest about two minutes, or pair pushes with pulls

    Two minutes works for most exercises and three for squats and deadlifts. Heavy one-rep-max work may need 4–5 minutes. To save time, alternate a press with a row or pull-down, which doesn't seem to hurt results.

  • 07

    Cardio rarely interferes with muscle gains

    Cardio blunts muscle growth mainly with very high volume done right before lifting, so avoid sprints before leg day. If strength is the priority, lift first and separate the two by several hours. Enjoyable outdoor activity counts, and high intensity mainly saves time. Walking needn't be obsessively tracked, and the 10,000-steps figure was more or less arbitrary.

  • 08

    No need to train by menstrual cycle phase

    The data don't support changing training by phase. Train hard and consistently, and adjust or skip a session if symptoms hit, but you aren't less capable during your period. Studies of combined oral contraceptives, which make up most of the research, show no effect on strength, muscle growth or power. Hormonal IUDs and patches are less studied.

  • 09

    Train the same way through perimenopause and menopause

    The goals don't change: build muscle and strength, maintain bone density and reduce the risk of falls and fractures. Maintaining nerve-to-muscle connections matters too, not just hormones. A gym's circuit of machines is a good starting point for women who are nervous about the weight room.

EXAMPLES

  • 01

    Fasted training makes no difference

    Long-term studies find the same muscle and fat-loss results whether people train fed or fasted. The 2012-era fasted-cardio craze didn't hold up, because extra fat burned during the workout doesn't change daily totals. The opposite fear, that fasted lifting costs muscle, also lacks support, since most lifting sessions don't drain stored carbohydrate. She trains fasted in the morning, always with caffeine, and never after 2 p.m. to protect her sleep.

  • 02

    The 'anabolic window' and the 30-gram limit

    Muscle protein synthesis stays elevated for up to 24 hours after lifting, so eating protein 30 minutes or 3 hours later makes no difference. Huberman cites a study suggesting people can use up to 100 g in one sitting. She says consistent daily and weekly protein intake matters more than per-meal timing or dosing.

  • 03

    Creatine gummies often contain little creatine

    When top-selling creatine gummies on Amazon were tested, some contained almost none, because the creatine is sometimes just sprayed on. She recommends 5 g a day of creatine monohydrate powder. It's safe and well studied, and the dose is the same for women. The benefit is modest: an extra rep or two, or a second off a sprint.

  • 04

    'Cortisol belly' is mostly marketing

    Real Cushing syndrome is uncommon and is usually a side effect of heavy steroid use. Its symptoms have been twisted into claims that any stress or belly fat 'must be cortisol' and that zone 2 or high-intensity training are harmful, mainly to sell supplements that don't work. Huberman adds that stress-related eating is the overlooked factor.

OTHER RELEVANT

  • 01

    Menopause hormone therapy aims to relieve symptoms

    Estrogen-based therapy aims to ease hot flashes, night sweats and poor sleep, not to restore premenopausal hormone levels. Feeling better can help women stick with training and diet. Testosterone for women is mainly proven for low libido, at low doses aiming for the low end of normal. Higher doses risk a deeper voice and unwanted hair, and there's no evidence low doses build muscle.

  • 02

    Add balance work to your strength sessions

    Instead of walking in a weighted vest (no substitute for lifting) or testing grip strength, she builds balance into lifting with single-leg Romanian deadlifts, walking lunges and full-range, multi-direction movements.

  • 03

    Keep caffeine consistent

    Most of caffeine's performance boost goes to people who don't normally drink it. Habitual users like her mainly notice the alertness.