Healing From Grief & Loss | Dr. Mary-Frances O'Connor
- Guest
- Dr. Mary-Frances O'Connor
- Read time
- ~5 min
- Uploaded
- 2 Jun 2025
- Duration
- 2:32:36
- Views
- 242.3K
KEYPOINTS
- 01
Grief and grieving are different things
O'Connor, who directs the Grief, Loss and Social Stress Lab at the University of Arizona, treats grief as an emotion: a wave that arrives whenever you remember your loved one is gone, even 25 years later. Grieving is the process of learning to live with the loss. She compares it to the stock market: some days are terrible, but over a year there is usually an upward trajectory.
- 02
The 'gone but also everlasting' conflict triggers waves of grief
Attachment comes with an implicit belief: I will always be there for you, and if you are absent I should search harder. After a death, your memory knows the person has died, but your attachment system still assumes they are out there somewhere. Each time you notice those two streams conflict, a wave of grief follows. That is why absence initially makes the longing stronger, not weaker.
- 03
Yearning engages the brain's reward-learning region
In her imaging work, bereaved people viewed photos of their deceased loved one versus a stranger. Greater self-reported yearning correlated directly with activity in the nucleus accumbens (ventral striatum), the same dopamine-linked region involved in wanting and addiction. Memory, emotion-regulation and autonomic areas were active in everyone, but yearning varied by person.
- 04
Yearning is closer to thirst than to addiction
O'Connor's analogy is a desert hike without water: you think of nothing else, but nobody calls that addiction. Attachment figures are basic needs, like food and water. Part of grieving is finding new ways to meet those needs, including someone else you can say 'I will always be there for you' to, because the person who died can no longer fill that role.
- 05
Healthy grieving moves through protest and despair, then transmutes them
Drawing on John Bowlby's attachment work, protest is the active searching state, driven by cortisol and adrenaline. Despair is withdrawal, which conserves resources but brings inflammation and shifts in prolactin and oxytocin. Both must be acknowledged, then turned into actions that keep the person's memory while you rebuild a life. Our innate ability to shift attachment from parents to peers in adolescence suggests we are built to make this adjustment.
- 06
Bereavement carries real medical risk
Large epidemiological studies show all-cause mortality rises in newly bereaved people, so 'dying of a broken heart' is not just a metaphor. In O'Connor's lab, blood pressure rose for everyone during a wave of grief, and it rose most in those reporting the most intense grief. A replication in Germany found their blood pressure did not recover.
- 07
The stage model was a description that became a prescription
Elisabeth Kübler-Ross's 1969 work was groundbreaking in showing that grief is more than sadness. However, her descriptive interviews were later treated as a fixed sequence. Disbelief, anger and acceptance can occur together, in any order, alongside many other feelings.
- 08
Oscillation is the sign of healthy grieving
The dual process model of bereavement describes moving back and forth between loss-oriented time (crying, barely able to make cereal) and restoration tasks such as doing the taxes for the first time. The ability to switch between the two, not steady progress in one direction, is the marker of health. There is no way to 'optimize' grieving.
- 09
Most people adapt, but about 1 in 10 develop disordered grief
Bodies and minds are remarkably resilient. For the roughly one in ten whose grief shows no change over time, O'Connor says specific evidence-based psychotherapy can restore a typical grieving trajectory, so professional help is worth seeking.
- 10
'If only' rumination is a form of protest
Guilt-laden stories about how the death could have been prevented are endless, and every one ends with 'and then they would have lived', which is not reality. Rumination can feel easier than accepting random tragedy, because it offers an illusion of control. But it pulls you out of the present. The better question is whether a thought is helpful, not whether it is true.
EXAMPLES
- 01
Progressive muscle relaxation beat mindfulness for widowed adults
In O'Connor's intervention study with widows and widowers, progressive muscle relaxation was meant to be the control condition, compared with mindfulness training and a waitlist. Mindfulness helped, but progressive relaxation helped grief even more. Participants could use it anywhere, and grieving brains may lack the bandwidth for a demanding new practice.
- 02
Primate mothers and the grooming rule
Observational studies show primate mothers carrying a dead infant for days to months and neglecting self-grooming. During that time, the troop's strict grooming hierarchy is suspended and anyone may groom her. O'Connor's lesson is that others should 'groom' the bereaved by prompting checkups and self-care that were neglected during caregiving.
- 03
Baby aspirin in the first two weeks
In a proof-of-concept study from her lab, replicated in Australia, bereaved people took low-dose aspirin for two weeks after the death and it was cardioprotective. O'Connor stresses it was not a randomized clinical trial and should not be taken as medical advice. Her point is that bereaved people should be treated as patients.
- 04
A beer for breakfast
The morning after her mother died, a restaurant owner in her Montana hometown offered her anything and she asked for a beer. She calls it the right tool at that moment because it let her cry with her best friend. Both she and Huberman stress that drinking to avoid feelings on an ongoing basis is harmful.
- 05
A widower who cried, then talked about dating
An older man in a UCLA study wept describing his wife's death two years earlier, then spoke happily about dinners with a new woman who brought out different parts of him. O'Connor uses this to show oscillation between loss and restoration.
OTHER RELEVANT
- 01
Try progressive muscle relaxation
Briefly tense and release muscle groups from head to toe, using free guided audio, and notice the contrast between clenched and relaxed. Practiced regularly, it becomes a portable tool for the grocery store, meetings or falling asleep.
- 02
Change your environment to break rumination
When you notice the 'if only' loop, physically get up and walk outside. O'Connor uses this herself. Focus on coping with the thoughts rather than answering them.
- 03
Support the body of a grieving person
Presence, touch, someone else in the room at night, bereavement groups, and nudges toward overdue medical, dental and mammogram appointments all matter. Support does not remove the pain, but it gives the body resources while it learns to regulate without the lost person.
- 04
Let difficult memories come rather than suppressing them
Avoiding images of the death can keep calling them up and suppressing them, which makes them more charged. Over time most people come to remember the life more than the death.
- 05
Seek help if nothing is shifting
If grief shows no change as months pass, targeted evidence-based therapy can help. Grief itself never fully disappears, and that is normal.