371 – Women’s sexual health: desire, arousal, and orgasms, navigating perimenopause, and more
- Guest
- Dr. Sally Greenwald
- Read time
- ~5 min
- Uploaded
- 3 Nov 2025
- Duration
- 2:00:42
- Views
- 278.8K
KEYPOINTS
- 01
Sexual health is part of physical health, and mismatched desire, not how often a couple has sex, predicts divorce.
OB-GYN Dr. Sally Greenwald notes the area is understudied and the data are mostly heterosexual. Orgasm shifts the body into parasympathetic mode and releases dopamine and oxytocin, and sleep metrics improve; women slept best after an orgasm with a partner, better than alone or after intimacy without orgasm. Sex burns about 6–7 METs (60–70 kcal per encounter). Among couples aged 30–60, about 20% have sex twice a week or more, about 10% not at all in the past year, and about 70% somewhere in between.
- 02
There's a large orgasm gap: about 95% of men versus about 30% of women regularly orgasm in partnered sex.
In one-night stands the figures are about 90% for men and 12% for women. Alone, women reach orgasm in under 4 minutes on average; with a partner it takes 21–25 minutes. When foreplay lasts more than 21 minutes, over 90% of women orgasm. Arousal lengthens and widens the vagina (about 3.5 by 9 inches at rest) and changes its angle, which matters because about 30% of women have pain with intercourse.
- 03
Most women have responsive desire rather than spontaneous desire.
Only about 15% of women feel desire in anticipation of sex; most feel it once arousal has started. That's why 'chore play', lubricant, vibrators, erotic audio or reading, and mindfulness (Lori Brotto's work) work better than waiting to be visually turned on. Emily Nagoski compares it to going to a party you weren't in the mood for and ending up enjoying it. Consent stays paramount, and stopping is always allowed.
- 04
The clitoris is a large, wishbone-shaped, often asymmetric organ with more than 8,000 nerve endings, and most women need external stimulation.
Fewer than 10% of women orgasm from penetration alone; a clitoris-to-vaginal-opening distance under about 1 inch makes it more likely. About 10% orgasm from the internal branch on the front wall (the 'G-spot', about a third of the way in, found with a 'come hither' motion); Dr. Lauren Streicher calls the other 90% normal. One side is often more sensitive. Only 41% of Gen Z men could identify the clitoris on a diagram.
- 05
Vibrators are evidence-based as nerves age, not a reflection on the partner.
Type A fibers, which sense vibration and deep pressure, are myelinated and age better than type C fibers, which sense light touch and heat. A couple whose usual routine stops working after decades may need an external wand or air-pulse device. Using a vibrator alone doesn't impair partnered orgasm if the technique is brought into partnered sex; 'orgasms beget orgasms' and 'sex begets sex'.
- 06
Testosterone is the best-studied treatment for hypoactive sexual desire disorder in postmenopausal women.
The diagnosis requires more than six months of low desire that bothers the woman herself, not just her partner. Greenwald prefers a compounded daily cream on the inner thigh (or about 0.5 cc of Testim via oral syringe), aims for total testosterone above about 20 (range 20–80 ng/dL), and titrates by symptoms. Estrogen raises SHBG, which binds testosterone; more androgenic progestins blunt that rise. Estrogen therapy tends to help desire indirectly, through better sleep and fewer hot flashes.
- 07
In perimenopause the first question is whether she wants to keep ovulating.
Some women love the energy and libido around ovulation (the late follicular phase is also a performance peak, so athletes time events to days 9–15), but 70–80% of her patients prefer not to cycle because of worsening PMS or PMDD, irregular cycles and heavy bleeding. Menopause hormone therapy doses don't suppress ovulation, while many contraceptives do. A meta-analysis of 32 trials (more than 14,000 women) found ovulation-suppressing contraception raised desire in 20%, left it unchanged in 65% and lowered it in 15%.
- 08
Lubricant is like sunscreen for the vagina: use it every time, ideally silicone and iso-osmolar.
It reduces micro-abrasions and the pain cycles that lead to vaginismus. Vaginal osmolality is about 300; Astroglide runs about 8,000 and KY about 4,000–6,000, which pull water out of tissue. She names Uber Lube (about 600) and Good Clean Love Almost Naked (280–300). She suggests applying it about 30 minutes before sex, using an applicator to place it higher up. Nightly moisturizers (Revaree hyaluronic acid, Replens) are the 'moisturizer', and local vaginal estrogen is the 'serum'. About 30–40% of her patients on systemic hormone therapy also need local estrogen.
EXAMPLES
- 01
Her perimenopause contraception menu.
For women who can't take estrogen: Slynd (drospirenone, a spironolactone derivative) suppresses ovulation in about 98% of women versus 50–70% for older progestin-only pills. Slynd plus an estradiol patch gives contraception with 'real' estrogen, at the cost of more breakthrough bleeding. Nextstellis pairs drospirenone with estetrol (E4), which causes less bloating and spotting, but bone data are pending. Natazia (estradiol valerate) is the only pill FDA-approved for heavy menstrual bleeding. Bioidentical-estrogen pills run about $100 a month and are rarely covered. Among synthetic pills she likes Lo Loestrin, Loestrin and Yaz/Yasmin.
- 02
'F*** it February'.
Couples schedule sex 2–3 times a week for the shortest month. The initiator stops fearing rejection, and the less interested partner is practicing responsive desire. She says desire stays elevated for months afterward.
- 03
Debut survey of 1,200 high schoolers.
70% of boys described their first sex in terms of pleasure and 70% of girls in terms of pain, which is her case for teaching foreplay and lubricant early.
- 04
The FDA-approved desire drugs are modest.
Addyi, a nightly pill taking about 6 weeks to work, added about one satisfying encounter a month over placebo; no alcohol, and it can cause nausea. Vyleesi, an injection related to PT-141 (the 'Barbie drug'), causes nausea in about 40%, can be used at most twice a week, and has been available since 2019. Sildenafil (25–50 mg) helps only specific groups: diabetics, MS, spinal cord injury and SSRI users. Where legal, 1–2 mg THC showed stronger effects in studies than either drug.
- 05
Sensate focus for trauma or a long break.
Dr. Leah Millheiser's four steps: touch without breasts or genitals, then genitals without orgasm, then orgasm without penetration, then intercourse. Each stage can last a week or longer.
OTHER RELEVANT
- 01
Advice for partners.
Use lube without taking it personally. Learn her anatomy, including which side is more sensitive. Invest in foreplay outside the bedroom. Near orgasm, don't change anything (about two-thirds of women want exactly the same stimulation to continue). Edging can intensify orgasm. Resources: Ian Kerner's She Comes First, Vanessa Marin's Sex Talks, OMGYes.
- 02
See a pelvic floor physical therapist as routine maintenance.
A stronger pelvic floor improves orgasm, and therapy also relaxes muscles that carry pain and stress. Local vaginal estrogen is considered safe for nearly all cancer survivors.
- 03
Postpartum: resume sex around 6 weeks after any birth.
High prolactin is a natural libido brake that helps space pregnancies about 18 months apart. Breastfeeding brings a menopause-like low-estrogen state in the vagina, for which she prescribes estrogen cream. Sex is safe through a healthy pregnancy unless there's a low-lying placenta or a short or weak cervix.
- 04
Teach kids accurate, pleasure-inclusive anatomy and consent.
Without it, teens learn from porn. Unprotected oral sex often carries more STI risk (for example, herpes) than penetrative sex with a condom.